JC polyoma viruria associates with protection from chronic kidney disease independently from apolipoprotein L1 genotype in African Americans | Zendy

Barry I. Freedman | Zendy; Amy Kistler | Zendy; Peter Skewes-Cox | Zendy; Don Ganem | Zendy; Mitzie Spainhour | Zendy; JoLyn Turner | Zendy; Jasmin Divers | Zendy; Carl D. Langefeld | Zendy; Mariana Murea | Zendy; Andrew A. Hicks | Zendy; Ashok K. Hemal | Zendy; James A. Snipes | Zendy; Lihong Zhao | Zendy; Johanna R. Abend | Zendy; Douglas S. Lyles | Zendy; Lijun Ma | Zendy; Karl Skorecki | Zendy

Open Access

JC polyoma viruria associates with protection from chronic kidney disease independently from apolipoprotein L1 genotype in African Americans

Author(s) -

Barry I. Freedman,

Amy Kistler,

Peter Skewes-Cox,

Don Ganem,

Mitzie Spainhour,

JoLyn Turner,

Jasmin Divers,

Carl D. Langefeld,

Mariana Murea,

Andrew A. Hicks,

Ashok K. Hemal,

James A. Snipes,

Lihong Zhao,

Johanna R. Abend,

Douglas S. Lyles,

Lijun Ma,

Karl Skorecki

Publication year - 2017

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfx368

Subject(s) - medicine , kidney disease , urine , genotype , nephropathy , odds ratio , kidney , jc virus , gastroenterology , diabetes mellitus , virology , immunology , endocrinology , biology , virus , progressive multifocal leukoencephalopathy , genetics , gene

Viral infections can trigger chronic kidney disease (CKD) and the urine virome may inform risk. The Natural History of APOL1-Associated Nephropathy Study (NHAANS) reported that urine JC polyomavirus (JCPyV) associated with a lower risk of APOL1-associated nephropathy in African Americans. Herein, association was assessed between urine JCPyV with CKD in African Americans independent from the APOL1 genotype.

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