Open AccessCirculating adiponectin modifies the FGF23 response to vitamin D receptor activation: a post hoc analysis of a double-blind, randomized clinical trial
Author(s) -
Belinda Spoto,
Patrizia Pizzini,
Giovanni Tripepi,
Francesca Mallamaci,
Carmine Zoccali
Publication year - 2017
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfx344
Subject(s) - paricalcitol , calcitriol receptor , adiponectin , medicine , endocrinology , fibroblast growth factor 23 , vitamin d and neurology , placebo , insulin resistance , parathyroid hormone , diabetes mellitus , secondary hyperparathyroidism , calcium , pathology , alternative medicine
The fibroblast growth factor 23 (FGF23) response to phosphate load is suppressed in adiponectin gene null mice and substantially amplified in mice overexpressing the same gene and vitamin D receptor (VDR) activation markedly enhances FGF23 gene expression.
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