Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy | Zendy

Wai Han Yiu | Zendy; Rui Xi Li | Zendy; Dickson W.L. Wong | Zendy; Hao Wu | Zendy; Kam Wa Chan | Zendy; Loretta Y.Y. Chan | Zendy; Joseph C.K. Leung | Zendy; Kar Neng Lai | Zendy; Steven H. Sacks | Zendy; Wuding Zhou | Zendy; Sydney C.W. Tang | Zendy

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Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy

Author(s) -

Wai Han Yiu,

Rui Xi Li,

Dickson W.L. Wong,

Hao Wu,

Kam Wa Chan,

Loretta Y.Y. Chan,

Joseph C.K. Leung,

Kar Neng Lai,

Steven H. Sacks,

Wuding Zhou,

Sydney C.W. Tang

Publication year - 2017

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfx336

Subject(s) - medicine , endocrinology , diabetic nephropathy , c5a receptor , fibrosis , kidney , complement system , immunology , immune system

Complement C5 mediates pro-inflammatory responses in many immune-related renal diseases. Given that the C5a level is elevated in diabetes, we investigated whether activation of C5a/C5aR signalling plays a pathogenic role in diabetic nephropathy (DN) and the therapeutic potential of C5a inhibition for renal fibrosis.

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