Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding | Zendy

Hiwa Ramadhan Fatah | Zendy; Nura F. Benfaed | Zendy; Ravinder S. Chana | Zendy; Mohamed H Chunara | Zendy; Jonathan Barratt | Zendy; Richard Baines | Zendy; Nigel J. Brunskill | Zendy

Open Access

Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding

Author(s) -

Hiwa Ramadhan Fatah,

Nura F. Benfaed,

Ravinder S. Chana,

Mohamed H Chunara,

Jonathan Barratt,

Richard Baines,

Nigel J. Brunskill

Publication year - 2017

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfx321

Subject(s) - proteinuria , receptor , endocrinology , medicine , endocytic cycle , kidney , messenger rna , endocytosis , excretion , biology , biochemistry , gene

Filtered proteins, including albumin, are reabsorbed in the proximal tubule (PT) mediated by megalin, cubilin and the neonatal Fc receptor (FcRn). Proteinuria is an important renal biomarker linked to poor prognosis but expression of these key receptors is not well studied.

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