Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction | Zendy

Weiwei Kong | Zendy; Jingqi Fu | Zendy; Nan Liu | Zendy; Congcong Jiao | Zendy; Guangying Guo | Zendy; Junjun Luan | Zendy; Huihui Wang | Zendy; Li Yao | Zendy; Lining Wang | Zendy; Masayuki Yamamoto | Zendy; Jingbo Pi | Zendy; Hua Zhou | Zendy

Open Access

Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction

Author(s) -

Weiwei Kong,

Jingqi Fu,

Nan Liu,

Congcong Jiao,

Guangying Guo,

Junjun Luan,

Huihui Wang,

Li Yao,

Lining Wang,

Masayuki Yamamoto,

Jingbo Pi,

Hua Zhou

Publication year - 2017

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfx299

Subject(s) - gclc , medicine , fibrosis , transdifferentiation , proliferating cell nuclear antigen , kidney , oxidative stress , inflammation , pathology , cancer research , endocrinology , downregulation and upregulation , biology , immunohistochemistry , microbiology and biotechnology , stem cell , biochemistry , gene

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a central mediator of cellular responses to oxidative stress. We hypothesized that Nrf2 modulates progression from acute tubular damage to renal fibrosis. We asked whether Nrf2 deletion increases renal injury in mice following unilateral ureteral obstruction (UUO).

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