Open AccessPregnancy-associated plasma protein-A predicts survival in end-stage renal disease—confounding and modifying effects of cardiovascular disease, body composition and inflammation
Author(s) -
Erik Nilsson,
Yang Cao,
Bengt Lindholm,
Ayane Ohyama,
Juan Jesús Carrero,
Abdul Rashid Qureshi,
Peter Stenvinkel
Publication year - 2017
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfx215
Subject(s) - confounding , disease , inflammation , end stage renal disease , medicine , pregnancy , biology , genetics
High pregnancy-associated plasma protein-A (PAPP-A) levels are linked to atherosclerosis and associate with increased mortality in prevalent dialysis patients. We investigated associations of PAPP-A, measured at dialysis initiation, with cardiovascular disease (CVD), CVD risk factors and mortality in incident dialysis patients, and explored if body composition and inflammation modulated these associations.
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