Open AccessLocal delivery of liposomal prednisolone leads to an anti-inflammatory profile in renal ischaemia–reperfusion injury in the rat
Author(s) -
Carla M. A. van Alem,
Mark C. Boonstra,
Jurriën Prins,
Taisiya Bezhaeva,
Mieke F. van Essen,
Jurjen M. Ruben,
Alexander L. Vahrmeijer,
Eric P. van der Veer,
Johan W. de Fijter,
Marlies E. J. Reinders,
Onno C. Meijer,
Josbert M. Metselaar,
Cees van Kooten,
Jan Rotmans
Publication year - 2017
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfx204
Subject(s) - prednisolone , liposome , medicine , pharmacology , kidney , renal ischemia , in vivo , ischemia , reperfusion injury , chemistry , biochemistry , biology , microbiology and biotechnology
Treatment of inflammatory kidney diseases with systemic high-dose glucocorticoids (GCs) has severe side effects. Liposomal encapsulation could facilitate local delivery of GCs to the inflamed kidney, as liposomes encapsulate their payload until extravasation at sites of inflammation, potentially resulting in local bioactivity. Our aim was to evaluate the ability of liposomes to accumulate locally after renal ischaemia-reperfusion injury in the rat and to study its effect on macrophages.
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