Open AccessRegulation of miR-29b and miR-30c by vitamin D receptor activators contributes to attenuate uraemia-induced cardiac fibrosis
Author(s) -
Sara Panizo,
Natalia CarrilloLópez,
Manuel NavesDíaz,
Guillermo Solache-Berrocal,
Laura MartínezArias,
Raúl R. Rodrigues-Díez,
Amalia Fernández-Vázquez,
Carlos MartínezSalgado,
Marta Ruiz–Ortega,
Adriana Dusso,
Jorge B. CannataAndía,
Isabel Rodrı́guez
Publication year - 2017
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfx060
Subject(s) - ctgf , medicine , paricalcitol , calcitriol receptor , endocrinology , fibrosis , myocardial fibrosis , cardiac fibrosis , vitamin d and neurology , growth factor , receptor , parathyroid hormone , secondary hyperparathyroidism , calcium
Uraemic cardiomyopathy, a process mainly associated with increased myocardial fibrosis, is the leading cause of death in chronic kidney disease patients and can be prevented by vitamin D receptor activators (VDRAs). Since some microRNAs (miRNAs) have emerged as regulators of the fibrotic process, we aimed to analyse the role of specific miRNAs in VDRA prevention of myocardial fibrosis as well as their potential use as biomarkers.
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