Open AccessFSTL3 is increased in renal dysfunction
Author(s) -
Susan Kralisch,
Annett Hoffmann,
Nora Klöting,
Anette Bachmann,
Jürgen Kratzsch,
JensUwe Stolzenburg,
Anja Dietel,
Joachim Beige,
Matthias Anders,
Ingolf Bast,
Matthias Blüher,
MingZhi Zhang,
Raymond C. Harris,
Michael Stümvoll,
Mathias Faßhauer,
Thomas Ebert
Publication year - 2017
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfw472
Subject(s) - medicine , renal function , endocrinology , kidney disease , follistatin , kidney , diabetes mellitus , downregulation and upregulation , biology , biochemistry , gene
Follistatin-like 3 (FSTL3) is a novel cytokine that regulates insulin sensitivity and counteracts activin/myostatin signalling. In the present study, regulation of FSTL3 in renal dysfunction was investigated in both human chronic kidney disease (CKD) and acute kidney dysfunction (AKD). Furthermore, mFSTL3 expression was analysed in insulin-sensitive tissues in a mouse model of CKD.
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