Open AccessA noninferiority trial comparing a heparin-grafted membrane plus citrate-containing dialysate versus regional citrate anticoagulation: results of the CiTED study
Author(s) -
Björn Meijers,
Christoph Metalidis,
Thomas Vanhove,
Ruben Poesen,
Dirk Kuypers,
Pieter Evenepoel
Publication year - 2017
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfw461
Subject(s) - medicine , heparin , activated clotting time , dialysis , hemodialysis , clinical endpoint , surgery , fondaparinux , randomized controlled trial , anesthesia , urology , thrombosis , venous thromboembolism
Anticoagulation is a prerequisite for successful haemodialysis. Heparin and low-molecular weight heparins are routinely used despite increased bleeding risk. Regional citrate anticoagulation (RCA) is efficacious, but is laborious and may induce metabolic disturbances. Heparin-grafted membranes are less efficacious. It is not known whether combining citrate-containing dialysate and a heparin-grafted membrane is a valid anticoagulation strategy.
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