A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy | Zendy

Karl Skorecki | Zendy; Jessica H. Lee | Zendy; Carl D. Langefeld | Zendy; Saharon Rosset | Zendy; Shay Tzur | Zendy; Walter G. Wasser | Zendy; Revital Shemer | Zendy; Gregory A. Hawkins | Zendy; Jasmin Divers | Zendy; Rulan S. Parekh | Zendy; Man Li | Zendy; Matthew G. Sampson | Zendy; Matthias Kretzler | Zendy; Martin R. Pollak | Zendy; Shrijal S. Shah | Zendy; Daniel Blackler | Zendy; Brendan Nichols | Zendy; Michael Wilmot | Zendy; Seth L. Alper | Zendy; Barry I. Freedman | Zendy; David J. Friedman | Zendy

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A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy

Author(s) -

Karl Skorecki,

Jessica H. Lee,

Carl D. Langefeld,

Saharon Rosset,

Shay Tzur,

Walter G. Wasser,

Revital Shemer,

Gregory A. Hawkins,

Jasmin Divers,

Rulan S. Parekh,

Man Li,

Matthew G. Sampson,

Matthias Kretzler,

Martin R. Pollak,

Shrijal S. Shah,

Daniel Blackler,

Brendan Nichols,

Michael Wilmot,

Seth L. Alper,

Barry I. Freedman,

David J. Friedman

Publication year - 2016

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfw451

Subject(s) - medicine , kidney disease , allele , diabetic nephropathy , odds ratio , diabetes mellitus , genetics , endocrinology , gene , biology

Inheritance of apolipoprotein L1 gene (APOL1) renal-risk variants in a recessive pattern strongly associates with non-diabetic end-stage kidney disease (ESKD). Further evidence supports risk modifiers in APOL1-associated nephropathy; some studies demonstrate that heterozygotes possess excess risk for ESKD or show earlier age at ESKD, relative to those with zero risk alleles. Nearby loci are also associated with ESKD in non-African Americans.

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