Causality at the dawn of the ‘omics’ era in medicine and in nephrology | Zendy

Carmine Zoccali | Zendy; Diego Brancaccio | Zendy; Marco J. Nathan | Zendy

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Causality at the dawn of the ‘omics’ era in medicine and in nephrology

Author(s) -

Carmine Zoccali,

Diego Brancaccio,

Marco J. Nathan

Publication year - 2016

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfw032

Subject(s) - causality (physics) , context (archaeology) , precision medicine , pace , causation , medicine , observational study , personalized medicine , data science , causal inference , epistemology , bioinformatics , computer science , pathology , biology , paleontology , philosophy , physics , geodesy , quantum mechanics , geography

Causality is a core concept in medicine. The quantitative determinacy characterizing today's biomedical science is unprecedented. The assessment of causal relations in human diseases is evolving, and it is therefore fundamental to keep up with the steady pace of theoretical and technological advancements. The exact specification of all causes of pathologies at the individual level, precision medicine, is expected to allow the complete eradication of disease. In this article, we discuss the various conceptualizations of causation that are at play in the context of randomized clinical trials and observational studies. Genomics, proteomics, metabolomics and epigenetics can now produce the precise knowledge we need for 21st century medicine. New conceptions of causality are needed to form the basis of the new precision medicine.

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