Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models | Zendy

Katrin Schindler | Zendy; Tzvetanka Bondeva | Zendy; Claudia Schindler | Zendy; Ralf A. Claus | Zendy; Sybille Franke | Zendy; Günter Wolf | Zendy

Open Access

Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models

Author(s) -

Katrin Schindler,

Tzvetanka Bondeva,

Claudia Schindler,

Ralf A. Claus,

Sybille Franke,

Günter Wolf

Publication year - 2016

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv442

Subject(s) - sepsis , medicine , kidney , acute kidney injury , endocrinology , immunology

Septic conditions contribute to tissue hypoxia, potentially leading to multiple organ failure, including acute kidney injury. The regulation of cellular adaptation to low oxygen levels is regulated by hypoxia-inducible transcription factors (HIFs). While the role of HIFs in ischaemia/reperfusion is more studied, their function in sepsis-induced renal injury is not well characterized. In this study, we investigated whether pharmacological activation of HIFs by suppression of prolyl-hydroxylases (PHDs) protects against septic acute kidney injury.

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