Increased phosphatidylserine-exposing microparticles and their originating cells are associated with the coagulation process in patients with IgA nephropathy | Zendy

Zhangxiu He | Zendy; Yan Zhang | Zendy; Muhua Cao | Zendy; Ruishuang Ma | Zendy; Huan Meng | Zendy; Zhipeng Yao | Zendy; Lu Zhao | Zendy; Yan Liu | Zendy; Xiaoming Wu | Zendy; Ruijuan Deng | Zendy; Zengxiang Dong | Zendy; Yayan Bi | Zendy; Junjie Kou | Zendy; Valerie A. Novakovic | Zendy; Jialan Shi | Zendy; Lirong Hao | Zendy

Open Access

Increased phosphatidylserine-exposing microparticles and their originating cells are associated with the coagulation process in patients with IgA nephropathy

Author(s) -

Zhangxiu He,

Yan Zhang,

Muhua Cao,

Ruishuang Ma,

Huan Meng,

Zhipeng Yao,

Lu Zhao,

Yan Liu,

Xiaoming Wu,

Ruijuan Deng,

Zengxiang Dong,

Yayan Bi,

Junjie Kou,

Valerie A. Novakovic,

Jialan Shi,

Lirong Hao

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv403

Subject(s) - phosphatidylserine , medicine , nephropathy , coagulation , fibrin , immunology , glomerulonephritis , pathology , membrane , kidney , endocrinology , diabetes mellitus , biochemistry , biology , phospholipid

Relatively little information is available about phosphatidylserine positive (PS(+)) microparticles (MPs) and their originating cells in IgA nephropathy (IgAN) despite well-established intraglomerular coagulation. Our objectives were to detect PS exposure on MP membranes and MP-origin cells and to evaluate its role in procoagulant activity (PCA) and fibrin formation and their association with pathological lesions in the disease.

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