Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure | Zendy

Ingrid A. Andersen | Zendy; Brenda K. Huntley | Zendy; Sharon Sandberg | Zendy; Denise M. Heublein | Zendy; John C. Burnett | Zendy

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Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure

Author(s) -

Ingrid A. Andersen,

Brenda K. Huntley,

Sharon Sandberg,

Denise M. Heublein,

John C. Burnett

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv398

Subject(s) - medicine , heart failure , acute decompensated heart failure , cardiology , natriuretic peptide , ejection fraction , fibroblast growth factor 23 , renal function , endocrinology , calcium , parathyroid hormone

Elevated plasma fibroblast growth factor 23 (FGF23) is a prognostic marker in chronic kidney disease. Recently, FGF23 was reported to also be a predictive factor in chronic congestive heart failure (HF). To date however, plasma levels in acute decompensated HF (ADHF) have not been reported and myocardial production and distribution of FGF23 in HF is poorly defined. We aimed to determine plasma levels and myocardial production of FGF23 in ADHF.

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