Impact of anti-glomerular basement membrane antibodies and glomerular neutrophil activation on glomerulonephritis in experimental myeloperoxidase-antineutrophil cytoplasmic antibody vasculitis | Zendy

Go Kanzaki | Zendy; Shinya Nagasaka | Zendy; Seiichiro Higo | Zendy; Yusuke Kajimoto | Zendy; Takafumi Kanemitsu | Zendy; Michiko Aoki | Zendy; Kiyotaka Nagahama | Zendy; Yasuhiro Natori | Zendy; Nobuo Tsuboi | Zendy; Takashi Yokoo | Zendy; Akira Shimizu | Zendy

Open Access

Impact of anti-glomerular basement membrane antibodies and glomerular neutrophil activation on glomerulonephritis in experimental myeloperoxidase-antineutrophil cytoplasmic antibody vasculitis

Author(s) -

Go Kanzaki,

Shinya Nagasaka,

Seiichiro Higo,

Yusuke Kajimoto,

Takafumi Kanemitsu,

Michiko Aoki,

Kiyotaka Nagahama,

Yasuhiro Natori,

Nobuo Tsuboi,

Takashi Yokoo,

Akira Shimizu

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv384

Subject(s) - medicine , anti neutrophil cytoplasmic antibody , myeloperoxidase , cxcl1 , glomerulonephritis , immunology , glomerular basement membrane , chemokine , proinflammatory cytokine , vasculitis , inflammation , pathology , kidney , disease

Antineutrophil cytoplasmic antibody (ANCA) and neutrophil interactions play important roles in ANCA-associated vasculitis (AAV) pathogenesis. However, mechanisms underlying the pathogenesis of crescent formation in ANCA-associated vasculitis have not been completely elucidated. To ascertain the involvement of these interactions in necrotizing crescentic glomerulonephritis (NCGN), we used an AAV rat model and investigated the effects of the anti-myeloperoxidase (MPO) antibody (Ab) titer, tumor necrosis factor α (TNF-α), granulocyte colony-stimulating factor (G-CSF) and subnephritogenic anti-glomerular basement membrane (GBM) Abs, as proinflammatory stimuli.

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