Oleanolic acid andN-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model | Zendy

Eun Soo Lee | Zendy; Hong Min Kim | Zendy; Jeong Suk Kang | Zendy; Eun Young Lee | Zendy; Dhananjay Yadav | Zendy; Mi-Hye Kwon | Zendy; You Mi Kim | Zendy; Hyeon Soo Kim | Zendy; Choon Hee Chung | Zendy

Open Access

Oleanolic acid andN-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model

Author(s) -

Eun Soo Lee,

Hong Min Kim,

Jeong Suk Kang,

Eun Young Lee,

Dhananjay Yadav,

Mi-Hye Kwon,

You Mi Kim,

Hyeon Soo Kim,

Choon Hee Chung

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv377

Subject(s) - oxidative stress , medicine , endocrinology , acetylcysteine , diabetic nephropathy , antioxidant , unfolded protein response , endoplasmic reticulum , malondialdehyde , superoxide dismutase , pharmacology , diabetes mellitus , chemistry , biochemistry

Hyperglycemia-induced endoplasmic reticulum (ER) stress and oxidative stress could be causes of renal fibrosis in diabetes. Oleanolic acid (OA) naturally occurs in fruits and vegetables. It has anti-inflammatory, antihyperlipidemic and antioxidant effects. N-acetylcysteine (NAC) is a precursor of glutathione, which has a strong antioxidant effect in the body. In this study, we investigated the therapeutic effects of OA and NAC in diabetic nephropathy (DN).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research