The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats | Zendy

Hitoshi Minakuchi | Zendy; Shu Wakino | Zendy; Kozi Hosoya | Zendy; Keiko Sueyasu | Zendy; Kazuhiro Hasegawa | Zendy; Keisuke Shinozuka | Zendy; Ayumi Yoshifuji | Zendy; Koji Futatsugi | Zendy; Motoaki Komatsu | Zendy; Takeshi Kanda | Zendy; Hirobumi Tokuyama | Zendy; Kôichi Hayashi | Zendy; Hiroshi Itoh | Zendy

Open Access

The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats

Author(s) -

Hitoshi Minakuchi,

Shu Wakino,

Kozi Hosoya,

Keiko Sueyasu,

Kazuhiro Hasegawa,

Keisuke Shinozuka,

Ayumi Yoshifuji,

Koji Futatsugi,

Motoaki Komatsu,

Takeshi Kanda,

Hirobumi Tokuyama,

Kôichi Hayashi,

Hiroshi Itoh

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv367

Subject(s) - medicine , endocrinology , adipose tissue , adipocyte , asymmetric dimethylarginine , insulin resistance , adipogenesis , lipodystrophy , white adipose tissue , insulin , chemistry , arginine , biochemistry , amino acid , family medicine , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load

The lipodystrophy-like phenotype has been suggested in early chronic kidney disease (CKD). It includes adipose tissue atrophy, systemic insulin resistance (IR), dyslipidemia and ectopic lipid accumulation. To elucidate its pathogenesis, we investigated the role of two uremic toxins that affect insulin sensitivity: an endogenous nitric oxide synthase inhibitor, and asymmetric dimethylarginine (ADMA) and indoxyl sulfate (IS).

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