Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials | Zendy

Sanne A. E. Peters | Zendy; Michiel L Bots | Zendy; Bernard Canaud | Zendy; Andrew Davenport | Zendy; Muriel P.C. Grooteman | Zendy; Fatih Kırçelli | Zendy; Francesco Locatelli | Zendy; Francisco Maduell | Zendy; Marion Moréna | Zendy; Menso J. Nubé | Zendy; Ercan Ok | Zendy; Ferrán Torres | Zendy; Mark Woodward | Zendy; P. J. Blankestijn | Zendy

Open Access

Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials

Author(s) -

Sanne A. E. Peters,

Michiel L Bots,

Bernard Canaud,

Andrew Davenport,

Muriel P.C. Grooteman,

Fatih Kırçelli,

Francesco Locatelli,

Francisco Maduell,

Marion Moréna,

Menso J. Nubé,

Ercan Ok,

Ferrán Torres,

Mark Woodward,

P. J. Blankestijn

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv349

Subject(s) - medicine , hazard ratio , proportional hazards model , kidney disease , confidence interval , randomized controlled trial , mortality rate , intensive care medicine

Mortality rates remain high for haemodialysis (HD) patients and simply increasing the HD dose to remove more small solutes does not improve survival. Online haemodiafiltration (HDF) provides additional clearance of larger toxins compared with standard HD. Randomized controlled trials (RCTs) comparing HDF with conventional HD on all-cause and cause-specific mortality in end-stage kidney disease (ESKD) patients reported inconsistent results and were at high risk of bias. We conducted a pooled individual participant data analysis of RCTs to provide the most reliable evidence to date on the effects of HDF on mortality outcomes in ESKD patients.

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