Citrate pharmacokinetics at high levels of circuit citratemia during coupled plasma filtration adsorption | Zendy

Filippo Mariano | Zendy; Maurizio Morselli | Zendy; Z.M. Holló | Zendy; Fulvio Agostini | Zendy; Maurizio Stella | Zendy; Luigi Biancone | Zendy

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Citrate pharmacokinetics at high levels of circuit citratemia during coupled plasma filtration adsorption

Author(s) -

Filippo Mariano,

Maurizio Morselli,

Z.M. Holló,

Fulvio Agostini,

Maurizio Stella,

Luigi Biancone

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv290

Subject(s) - medicine , pharmacokinetics , urology , anesthesia

The heparin requirement for coupled plasma filtration adsorption (CPFA) is usually high. Heparin administration often cannot be adherent to prescription, leading to a premature clotting of circuit and an insufficient volume of treated plasma. Regional citrate anticoagulation (RCA) could be an attractive alternative; however, no data are available on citrate pharmacokinetics at high levels of circuit citratemia.

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