Icodextrin reduces insulin resistance in non-diabetic patients undergoing automated peritoneal dialysis: results of a randomized controlled trial (STARCH) | Zendy

Thyago Proença de Moraes | Zendy; Maria Cláudia Cruz Andreoli | Zendy; María Eugênia Fernandes Canziani | Zendy; Dirceu Reis da Silva | Zendy; Jacqueline Costa Teixeira Caramori | Zendy; Daniela Ponce | Zendy; Hélio Vida Cassi | Zendy; Kleyton de Andrade Bastos | Zendy; Danyelle Romana Alves Rio | Zendy; Sérgio Wyton Lima Pinto | Zendy; Sebastião Rodrigues Ferreira Filho | Zendy; Ludimila Guedim de Campos | Zendy; Márcia Olandoski | Zendy; José Carolino DivinoFilho | Zendy; Roberto Pecoits–Filho | Zendy

Open Access

Icodextrin reduces insulin resistance in non-diabetic patients undergoing automated peritoneal dialysis: results of a randomized controlled trial (STARCH)

Author(s) -

Thyago Proença de Moraes,

Maria Cláudia Cruz Andreoli,

María Eugênia Fernandes Canziani,

Dirceu Reis da Silva,

Jacqueline Costa Teixeira Caramori,

Daniela Ponce,

Hélio Vida Cassi,

Kleyton de Andrade Bastos,

Danyelle Romana Alves Rio,

Sérgio Wyton Lima Pinto,

Sebastião Rodrigues Ferreira Filho,

Ludimila Guedim de Campos,

Márcia Olandoski,

José Carolino DivinoFilho,

Roberto Pecoits–Filho

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv247

Subject(s) - medicine , icodextrin , insulin resistance , peritoneal dialysis , randomization , randomized controlled trial , diabetes mellitus , kidney disease , gastroenterology , insulin , surgery , endocrinology

Insulin resistance is a common risk factor in chronic kidney disease patients contributing to the high cardiovascular burden, even in the absence of diabetes. Glucose-based peritoneal dialysis (PD) solutions are thought to intensify insulin resistance due to the continuous glucose absorption from the peritoneal cavity. The aim of our study was to analyse the effect of the substitution of glucose for icodextrin on insulin resistance in non-diabetic PD patients in a multicentric randomized clinical trial.

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