Iohexol plasma clearance measurement in older adults with chronic kidney disease—sampling time matters | Zendy

Natalie Ebert | Zendy; Amina Loesment | Zendy; Peter Martus | Zendy; Olga Jakob | Zendy; Jens Gaedeke | Zendy; Martin K. Kuhlmann | Zendy; Jan Bartel | Zendy; Mirjam Schuchardt | Zendy; Markus Tölle | Zendy; Tao Huang | Zendy; Markus van der Giet | Zendy; Elke Schäeffner | Zendy

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Iohexol plasma clearance measurement in older adults with chronic kidney disease—sampling time matters

Author(s) -

Natalie Ebert,

Amina Loesment,

Peter Martus,

Olga Jakob,

Jens Gaedeke,

Martin K. Kuhlmann,

Jan Bartel,

Mirjam Schuchardt,

Markus Tölle,

Tao Huang,

Markus van der Giet,

Elke Schäeffner

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv116

Subject(s) - medicine , iohexol , kidney disease , renal function , plasma clearance , urology , mean difference , pharmacokinetics , nuclear medicine , confidence interval

Accurate and precise measurement of GFR is important for patients with chronic kidney disease (CKD). Sampling time of exogenous filtration markers may have great impact on measured GFR (mGFR) results, but there is still uncertainty about optimal timing of plasma clearance measurement in patients with advanced CKD, for whom 24-h measurement is recommended. This satellite project of the Berlin Initiative Study evaluates whether 24-h iohexol plasma clearance reveals a clinically relevant difference compared with 5-h measurement in older adults.

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