AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress | Zendy

Mikito Nishikawa | Zendy; Naoki Ishimori | Zendy; Shingo Takada | Zendy; Akimichi Saito | Zendy; Tomoyasu Kadoguchi | Zendy; Takaaki Furihata | Zendy; Arata Fukushima | Zendy; Shouji Matsushima | Zendy; Takashi Yokota | Zendy; Shintaro Kinugawa | Zendy; Hiroyuki Tsutsui | Zendy

Open Access

AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress

Author(s) -

Mikito Nishikawa,

Naoki Ishimori,

Shingo Takada,

Akimichi Saito,

Tomoyasu Kadoguchi,

Takaaki Furihata,

Arata Fukushima,

Shouji Matsushima,

Takashi Yokota,

Shintaro Kinugawa,

Hiroyuki Tsutsui

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv103

Subject(s) - medicine , endocrinology , oxidative stress , kidney disease , skeletal muscle , mitochondrial biogenesis , mitochondrion , biochemistry , biology

Exercise capacity and quality of life are markedly impaired in chronic kidney disease (CKD). Increased plasma uremic toxins such as indoxyl sulfate (IS), which induce oxidative stress, may be involved in this process. An oral adsorbent, AST-120, can reduce circulating IS, however, its effects on skeletal muscle and exercise capacity have not been investigated in CKD.

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