Circulating Wnt/β-catenin signalling inhibitors and uraemic vascular calcifications | Zendy

ChihYu Yang | Zendy; ZeeFen Chang | Zendy; YatPang Chau | Zendy; Ann Chen | Zendy; Wu-Chang Yang | Zendy; An-Hang Yang | Zendy; Oscar K. Lee | Zendy

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Circulating Wnt/β-catenin signalling inhibitors and uraemic vascular calcifications

Author(s) -

ChihYu Yang,

ZeeFen Chang,

YatPang Chau,

Ann Chen,

Wu-Chang Yang,

An-Hang Yang,

Oscar K. Lee

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv043

Subject(s) - sclerostin , medicine , wnt signaling pathway , endocrinology , dialysis , hazard ratio , prospective cohort study , calcification , parathyroid hormone , signal transduction , calcium , confidence interval , biochemistry , chemistry

The process of vascular calcification has been associated with the canonical Wnt/β-catenin signalling pathway in cell cultures and animal studies. The relationship between circulating Wnt/β-catenin inhibitors and vascular calcification in dialysis patients is unknown. The aim of this study was to investigate the associations between serum dickkopf-1 (Dkk-1) and sclerostin, two circulating inhibitors of the Wnt/β-catenin signalling pathway, and the severity of aortic calcification (AoC) and cardiovascular outcomes in dialysis patients.

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