Role of let-7b in the regulation ofN-acetylgalactosaminyltransferase 2 in IgA nephropathy | Zendy

Grazia Serino | Zendy; Fabio Sallustio | Zendy; Claudia Curci | Zendy; Sharon Natasha Cox | Zendy; Francesco Pesce | Zendy; Giuseppe De Palma | Zendy; Francesco Paolo Schena | Zendy

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Role of let-7b in the regulation ofN-acetylgalactosaminyltransferase 2 in IgA nephropathy

Author(s) -

Grazia Serino,

Fabio Sallustio,

Claudia Curci,

Sharon Natasha Cox,

Francesco Pesce,

Giuseppe De Palma,

Francesco Paolo Schena

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv032

Subject(s) - peripheral blood mononuclear cell , downregulation and upregulation , nephropathy , glycosylation , ex vivo , microarray analysis techniques , transfection , immunology , medicine , biology , in vivo , gene expression , gene , in vitro , endocrinology , biochemistry , genetics , diabetes mellitus

IgA nephropathy (IgAN) is characterized by aberrant O-glycosylation in the hinge region of IgA1. The early step in O-glycan formation is the attachment of N-acetylgalactosamine (GalNAc) to the serine/threonine of the hinge region; the process is catalysed by UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2). In our previous work, the microarray analysis on peripheral blood mononuclear cells (PBMCs) identified an upregulated miRNA called let-7b.

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