Disappearance of immunoglobulins from persistent renal amyloid deposits following stem cell transplantation for heavy-and light-chain amyloidosis
Author(s) -
Sami Safadi,
Ahmed Saad,
Patrick Quint,
Sanjeev Sethi,
Nelson Leung,
Paul J. Kurtin,
Samih H. Nasr
Publication year - 2015
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfv018
Subject(s) - amyloidosis , immunoglobulin light chain , medicine , pathology , amyloid (mycology) , al amyloidosis , autologous stem cell transplantation , kidney , transplantation , kidney transplantation , monoclonal , antibody , monoclonal antibody , immunology
Immunoglobulin (Ig)-related amyloidosis is the most common type of systemic amyloidosis in the developed countries and involves the kidney in most cases. Clinical remission can be achieved with chemotherapy and/or autologous stem cell transplantation (ASCT). Previous case reports have showed persistence of renal amyloid mass in light-chain amyloidosis (AL) even in the setting of hematologic and renal response.
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