Protective role of cyclosporine A and minocycline on mitochondrial disequilibrium-related podocyte injury and proteinuria occurrence induced by adriamycin | Zendy

Na Guan | Zendy; Ya-Li Ren | Zendy; Xiaoya Liu | Zendy; Ying Zhang | Zendy; Pei Pei | Zendy; Sainan Zhu | Zendy; Qingfeng Fan | Zendy

Open Access

Protective role of cyclosporine A and minocycline on mitochondrial disequilibrium-related podocyte injury and proteinuria occurrence induced by adriamycin

Author(s) -

Na Guan,

Ya-Li Ren,

Xiaoya Liu,

Ying Zhang,

Pei Pei,

Sainan Zhu,

Qingfeng Fan

Publication year - 2015

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfv015

Subject(s) - podocyte , podocin , mitochondrion , medicine , microbiology and biotechnology , apoptosis , annexin , endocrinology , biology , kidney , proteinuria , biochemistry

Dysfunction of mitochondria is involved in podocyte injury in some kidney diseases, but the relationship between abnormal mitochondrial morphology and podocyte injury as well as the underlying mechanism is still unclear. This study aims to investigate dynamic changes of mitochondrial morphology and the potential molecular events in an adriamycin (ADR)-induced podocyte injury model.

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