Open AccessAngiotensin II-mediated GFR decline in subtotal nephrectomy is due to acid retention associated with reduced GFR
Author(s) -
Donald E. Wesson,
Chan-Hee Jo,
Jane M. Simoni
Publication year - 2014
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfu388
Subject(s) - endocrinology , medicine , renal function , nephrectomy , angiotensin ii , antagonism , kidney , receptor
Angiotensin II (AII) mediates glomerular filtration rate (GFR) decline in animals with subtotal nephrectomy (Nx), but the mechanisms for increased AII activity are unknown. Because reduced GFR of Nx is associated with acid (H(+)) retention that increases kidney AII, AII-mediated GFR decline might be induced by H(+) retention.
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