Open AccessIncreased peritoneal damage in glyoxalase 1 knock-down mice treated with peritoneal dialysis
Author(s) -
Lars Kihm,
Sandra Müller-Krebs,
Sandra Holoch,
Svenja Schmuck,
Luís Eduardo Becker,
Michael Brownlee,
Martin Zeier,
Thomas Fleming,
Peter P. Nawroth,
Vedat Schwenger
Publication year - 2014
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfu346
Subject(s) - methylglyoxal , medicine , peritoneal dialysis , lactoylglutathione lyase , detoxification (alternative medicine) , peritoneum , fibrosis , pharmacology , biochemistry , surgery , pathology , enzyme , chemistry , alternative medicine
Peritoneal dialysis (PD) is limited by peritoneal fibrosis and ultrafiltration failure. This is in part caused by the high concentration of glucose degradation products (GDPs) present in PD fluids (PDF) as a consequence of heat sterilization. Existing research in long-term PD has mainly dealt with the toxicity induced by GDPs and the development of therapeutic strategies to reduce the cellular burden of GDPs. Currently, there are few data regarding the potential role of detoxification systems of GDP in PD. In this study, the role of glyoxalase 1 (Glo1), the major detoxification pathway for dicarbonyl-derived GD such as methylglyoxal (MG) and glyoxal (Gx), was investigated in vivo using heterozygous knock-down mice for Glo1 (Glo1(-/+)).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom