Open AccessHigh-volume online haemodiafiltration improves erythropoiesis-stimulating agent (ESA) resistance in comparison with low-flux bicarbonate dialysis: results of the REDERT study
Author(s) -
Vincenzo Panichi,
A. Scatena,
Alberto Rosati,
Robert Giusti,
Giovanna Ferro,
E. Malagnino,
A. Capitanini,
A. Piluso,
Paolo Conti,
G. Bernabini,
M. Migliori,
David Caiani,
Ciro Tetta,
A. Casani,
G. Betti,
Francesco Pizzarelli
Publication year - 2014
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfu345
Subject(s) - medicine , bicarbonate , erythropoiesis , dialysis , volume (thermodynamics) , intensive care medicine , flux (metallurgy) , urology , anemia , physics , materials science , quantum mechanics , metallurgy
In haemodialysis (HD) patients, anaemia is associated with reduced survival. Despite treatment with erythropoiesis-stimulating agents (ESAs), a large number of patients with chronic kidney disease show resistance to this therapy and require much higher than usual doses of ESAs in order to maintain the recommended haemoglobin (Hb) target, and recent studies suggest that hepcidin (HEP) may mediate the ESA resistance index (ERI). High-volume online haemodiafiltration (HV-OL-HDF) has been shown to improve anaemia and to reduce the need for ESAs in HD patients; this effect is associated with a reduced inflammatory state in these patients. The aim of the REDERT study (role of haemodiafiltration on ERI) was to investigate the effect of different dialysis techniques on ERI and HEP levels in chronic dialysis patients.
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