Open AccessThe effect of FoxO1 on the proliferation of rat mesangial cells under high glucose conditions
Author(s) -
Fei Liu,
Xiaolong Ma,
Qingzhu Wang,
Yanyan Zhao,
Liping Wu,
Guijun Qin
Publication year - 2014
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfu202
Subject(s) - foxo1 , diabetic nephropathy , medicine , endocrinology , mesangial cell , cell growth , renal cortex , nephropathy , pathological , transcription factor , cancer research , diabetes mellitus , signal transduction , protein kinase b , kidney , microbiology and biotechnology , biology , gene , biochemistry
Hyperproliferation of glomerular mesangial cells (MCs) is a major pathological characteristic in the early stage of diabetic nephropathy (DN). We have previously confirmed that forkhead transcription factor O1 (FoxO1) was significantly downregulated in both the renal cortex of DN rats and MCs cultured under high-glucose (HG) conditions, but the effects and mechanisms of FoxO1 involved in the hyperproliferation of MCs are still unclear. This study aims to investigate whether FoxO1 regulates the hyperproliferation of MCs induced under high-glucose conditions, through modulating the cyclin-dependent kinase inhibitor (CKI), p27.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom