Open AccessEpigenetics: a new way to look at kidney diseases
Author(s) -
Pazit Beckerman,
Yi-An Ko,
Katalin Suszták
Publication year - 2014
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfu026
Subject(s) - epigenetics , epigenomics , medicine , nephrology , computational biology , epigenesis , genetics , gene , kidney disease , genome , bioinformatics , human genome , dna methylation , biology , gene expression
Only a few percent of the 3 billion pairs of chemical letters in the human genome is responsible for protein-coding sequences. Recent advances in the field of epigenomics have helped us to understand how most of the remaining sequences are responsible for gene regulation at baseline and in disease conditions. Here we discuss recent advances in the area of epigenetics--specifically in cytosine modifications--and its application in the field of nephrology.