Open AccessImpaired renal growth hormone JAK/STAT5 signaling in chronic kidney disease
Author(s) -
D. Wiezel,
M. H. Assadi,
Danny Landau,
A. Troib,
Leonid Kachko,
Ralph Rabkin,
Yael Segev
Publication year - 2014
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfu003
Subject(s) - medicine , growth hormone receptor , endocrinology , kidney disease , socs3 , stat5 , kidney , receptor , hormone , growth hormone , cancer , suppressor
Treatment with recombinant human growth hormone (GH) is the standard therapy for short stature in children with chronic kidney disease (CKD). However, concerns have been raised on the potential renal fibrogenic effects of GH. There is no information regarding the renal GH receptor (GHR)-JAK-STAT signaling pathway in CKD.
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