The effects of both single-locus and multi-locus interaction on the clinical manifestations of IgA nephropathy in Southern Han Chinese | Zendy

Wei Wang | Zendy; Yu Sun | Zendy; Yonggui Fu | Zendy; Xueqing Yu | Zendy; Ming Li | Zendy

Open Access

The effects of both single-locus and multi-locus interaction on the clinical manifestations of IgA nephropathy in Southern Han Chinese

Author(s) -

Wei Wang,

Yu Sun,

Yonggui Fu,

Xueqing Yu,

Ming Li

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft468

Subject(s) - medicine , locus (genetics) , nephropathy , genetics , gene , endocrinology , diabetes mellitus , biology

Immunoglobulin A nephropathy (IgAN) is one of the most common types of glomerulonephritis throughout the world. It is considered to be a complex disease, to which both genetic and environmental factors contribute. Our previous study has shown a potential interaction of C1GALT1-330G/T and IL5RA31 + 197A/G on the susceptibility of IgAN in Southern Han Chinese. However, the interaction of these gene polymorphisms and the clinical manifestation for IgAN has not been investigated.

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