Intra-renal transfection of heat shock protein 90 alpha or beta (Hsp90 or Hsp90 ) protects against ischemia/reperfusion injury | Zendy

Jonatan BarreraChimal | Zendy; Rosalba PérezVillalva | Zendy; Juan Antonio Ortega-Trejo | Zendy; Norma Uribe | Zendy; Gerardo Gamba | Zendy; Cesar CortésGonzález | Zendy; Norma A. Bobadilla | Zendy

Open Access

Intra-renal transfection of heat shock protein 90 alpha or beta (Hsp90 or Hsp90 ) protects against ischemia/reperfusion injury

Author(s) -

Jonatan BarreraChimal,

Rosalba PérezVillalva,

Juan Antonio Ortega-Trejo,

Norma Uribe,

Gerardo Gamba,

Cesar CortésGonzález,

Norma A. Bobadilla

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft415

Subject(s) - medicine , heat shock protein , hsp90 , transfection , alpha (finance) , ischemia , reperfusion injury , beta (programming language) , shock (circulatory) , renal ischemia , gene , biochemistry , surgery , biology , construct validity , computer science , patient satisfaction , programming language

We previously reported that radicicol (Hsp90 inhibitor) induced a reduction in the renal blood flow and glomerular filtration rate, in part due to a reduction in urinary NO2/NO3 excretion, suggesting that Hsp90 regulates renal vascular tone in physiological conditions. However, there is a lack of information concerning Hsp90α or Hsp90β role on eNOS activity and their association with acute kidney injury (AKI) characterized by an inadequate NO production. This study evaluated the effects of Hsp90α or Hsp90β intra-renal transfection under ischemia/reperfusion (IR) injury.

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