Fluid flow shear stress over podocytes is increased in the solitary kidney | Zendy

Tarak Srivastava | Zendy; Gianni Celsi | Zendy; Mukut Sharma | Zendy; Hongying Dai | Zendy; Ellen T. McCarthy | Zendy; Melanie Ruiz | Zendy; Patricia A. Cudmore | Zendy; Uri S. Alon | Zendy; Ram Sharma | Zendy; Virginia A. Savin | Zendy

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Fluid flow shear stress over podocytes is increased in the solitary kidney

Author(s) -

Tarak Srivastava,

Gianni Celsi,

Mukut Sharma,

Hongying Dai,

Ellen T. McCarthy,

Melanie Ruiz,

Patricia A. Cudmore,

Uri S. Alon,

Ram Sharma,

Virginia A. Savin

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft387

Subject(s) - podocyte , renal function , medicine , kidney , kidney disease , endocrinology , nephron , muscle hypertrophy , stereology , filtration fraction , urology , renal blood flow , proteinuria

Glomerular hyperfiltration is emerging as the key risk factor for progression of chronic kidney disease (CKD). Podocytes are exposed to fluid flow shear stress (FFSS) caused by the flow of ultrafiltrate within Bowman's space. The mechanism of hyperfiltration-induced podocyte injury is not clear. We postulated that glomerular hyperfiltration in solitary kidney increases FFSS over podocytes.

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