The CTLA-4 +49GG genotype is associated with susceptibility for nephrotic kidney diseases | Zendy

Clemens Spink | Zendy; Gerben Stege | Zendy; Klaus Tenbrock | Zendy; Sigrid Harendza | Zendy

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The CTLA-4 +49GG genotype is associated with susceptibility for nephrotic kidney diseases

Author(s) -

Clemens Spink,

Gerben Stege,

Klaus Tenbrock,

Sigrid Harendza

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft381

Subject(s) - focal segmental glomerulosclerosis , nephrotic syndrome , medicine , membranous nephropathy , genotype , single nucleotide polymorphism , pathogenesis , minimal change disease , odds ratio , glomerulonephritis , immunology , kidney disease , nephropathy , kidney , gastroenterology , endocrinology , gene , biology , genetics , diabetes mellitus

The pathogenesis of primary nephrotic kidney diseases is not completely understood. As T-cell involvement is suspected, cytotoxic T-lymphocyte antigen 4 (CTLA-4) expressed on activated T cells could play a role in the immune response. Single-nucleotide polymorphisms (SNPs) in the CTLA-4 gene are associated with several autoimmune-related diseases.

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