p-Cresyl sulphate has pro-inflammatory and cytotoxic actions on human proximal tubular epithelial cells | Zendy

Jonay Poveda | Zendy; María Dolores Sánchez-Niño | Zendy; Griet Glorieux | Zendy; Ana B. Sanz | Zendy; Jesús Egido | Zendy; Raymond Vanholder | Zendy; Alberto Ortíz | Zendy

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p-Cresyl sulphate has pro-inflammatory and cytotoxic actions on human proximal tubular epithelial cells

Author(s) -

Jonay Poveda,

María Dolores Sánchez-Niño,

Griet Glorieux,

Ana B. Sanz,

Jesús Egido,

Raymond Vanholder,

Alberto Ortíz

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft367

Subject(s) - apoptosis , flow cytometry , medicine , cytotoxic t cell , programmed cell death , nephrotoxicity , toxicity , inflammation , microbiology and biotechnology , cancer research , pharmacology , endocrinology , immunology , biology , biochemistry , in vitro

p-Cresyl sulphate (p-CS) and p-cresyl glucuronide (p-CG) are uraemic toxins that exhibit pro-inflammatory features in leukocytes and are associated with the progression of chronic kidney disease (CKD). Tubular cells are key targets of nephrotoxic agents and tubular cell death and activation contribute to the progression of CKD. However, the potential toxicity of these compounds on tubular cells is not fully understood. More specifically, apoptosis has never been studied.

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