Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis | Zendy

Kenichiro Miura | Zendy; Hidetake Kurihara | Zendy; Shigeru Horita | Zendy; Hiroko Chikamoto | Zendy; Motoshi Hattori | Zendy; Yutaka Harita | Zendy; Haruko Tsurumi | Zendy; Yuko Kajiho | Zendy; Yoko Sawada | Zendy; Satoshi Sasaki | Zendy; Takashi Igarashi | Zendy; Shinji Kunishima | Zendy; Takashi Sekine | Zendy

Open Access

Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis

Author(s) -

Kenichiro Miura,

Hidetake Kurihara,

Shigeru Horita,

Hiroko Chikamoto,

Motoshi Hattori,

Yutaka Harita,

Haruko Tsurumi,

Yuko Kajiho,

Yoko Sawada,

Satoshi Sasaki,

Takashi Igarashi,

Shinji Kunishima,

Takashi Sekine

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft350

Subject(s) - podocyte , nephrin , medicine , synaptopodin , focal segmental glomerulosclerosis , glomerulosclerosis , nephrotic syndrome , slit diaphragm , nephrosis , podocin , immunoelectron microscopy , endocrinology , pathology , immunohistochemistry , glomerulonephritis , kidney , proteinuria

Previous studies have identified significant associations between the development of idiopathic focal segmental glomerulosclerosis (FSGS) and MYH9 encoding nonmuscle myosin heavy chain-IIA (NMMHC-IIA). However, these studies focused only on the linkage of MYH9 polymorphisms and development of FSGS. There have been no reports on pathological changes of NMMHC-IIA in human glomerular diseases. Here we report on the precise localization of NMMHC-IIA in podocytes and changes in NMMHC-IIA expression in pathological states in rats and humans.

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