Determination of uromodulin in human urine: influence of storage and processing | Zendy

Sonia Youhanna | Zendy; Julien Weber | Zendy; Viviane Beaujean | Zendy; Bob Glaudemans | Zendy; Jens Sobek | Zendy; Olivier Devuyst | Zendy

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Determination of uromodulin in human urine: influence of storage and processing

Author(s) -

Sonia Youhanna,

Julien Weber,

Viviane Beaujean,

Bob Glaudemans,

Jens Sobek,

Olivier Devuyst

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft345

Subject(s) - tamm–horsfall protein , urine , medicine , kidney , biomarker , kidney disease , urinary system , endocrinology , biology , biochemistry

Uromodulin (Tamm-Horsfall protein) is the most abundant protein excreted in the urine under physiological conditions. It is exclusively produced in the kidney and secreted into the urine via proteolytic cleavage. The involvement of UMOD, the gene that encodes uromodulin, in rare autosomal dominant diseases, and its robust genome-wide association with the risk of chronic kidney disease suggest that the level of uromodulin in urine could represent a critical biomarker for kidney function. The structure of uromodulin is complex, with multiple disulfide bonds and typical domains of extracellular proteins.

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