Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol | Zendy

Kiichiro Fujisaki | Zendy; Kazuhiko Tsuruya | Zendy; Mayumi Yamato | Zendy; Jiro Toyonaga | Zendy; H. Noguchi | Zendy; Toshiaki Nakano | Zendy; M. Taniguchi | Zendy; Masanori Tokumoto | Zendy; Hiroyuki HIRAKATA | Zendy; Takanari Kitazono | Zendy

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Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol

Author(s) -

Kiichiro Fujisaki,

Kazuhiko Tsuruya,

Mayumi Yamato,

Jiro Toyonaga,

H. Noguchi,

Toshiaki Nakano,

M. Taniguchi,

Masanori Tokumoto,

Hiroyuki HIRAKATA,

Takanari Kitazono

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft327

Subject(s) - oxidative stress , uremia , medicine , neuroprotection , hippocampus , endocrinology , kidney disease , cognitive decline , hippocampal formation , pharmacology , dementia , disease

Chronic kidney disease (CKD) is frequently associated with uremic encephalopathy and cognitive impairment. Recent studies have demonstrated that cerebral oxidative stress contributes to cognitive dysfunction. Although oxidative stress has been reported to increase in the uremic rat brain, the relationship between increased oxidative stress and cognitive impairment in uremia is unclear. In the present study, the effects of tempol (TMP), an antioxidant drug, were investigated in uremic mice.

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