Expression of the transcriptional regulator snail1 in kidney transplants displaying epithelial-to-mesenchymal transition features | Zendy

Yi-Chun Xu-Dubois | Zendy; Pierre Galichon | Zendy; Isabelle Brochériou | Zendy; Edith Baugey | Zendy; Romain Morichon | Zendy; Chantal Jouanneau | Zendy; Nacéra Ouali | Zendy; Éric Rondeau | Zendy; Alexandre Hertig | Zendy

Open Access

Expression of the transcriptional regulator snail1 in kidney transplants displaying epithelial-to-mesenchymal transition features

Author(s) -

Yi-Chun Xu-Dubois,

Pierre Galichon,

Isabelle Brochériou,

Edith Baugey,

Romain Morichon,

Chantal Jouanneau,

Nacéra Ouali,

Éric Rondeau,

Alexandre Hertig

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft279

Subject(s) - epithelial–mesenchymal transition , smad , medicine , regulator , context (archaeology) , mesenchymal stem cell , transplantation , cancer research , microrna , transforming growth factor , mesenchyme , epithelium , kidney , fibrosis , metastasis , pathology , microbiology and biotechnology , gene , cancer , biology , paleontology , biochemistry

The epithelial response to injury is stereotypical and reminiscent of epithelial-to-mesenchymal transitions (EMTs), such as those observed during embryogenesis and tumour metastasis. In the context of solid organ transplantation, EMT-like features are often acquired by epithelial cells and are predictive of graft fibrosis. Here, we studied the possible involvement of several major transcriptional regulators, including snail1, phospho-Smad 2/3 and zeb1, in EMT induction in human renal grafts.

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