Sclerostin: another bone-related protein related to all-cause mortality in haemodialysis? | Zendy

Liesbeth Viaene | Zendy; Geert J. Behets | Zendy; Kathleen Claes | Zendy; Björn Meijers | Zendy; Frank Blocki | Zendy; Vincent Brandenburg | Zendy; P. Evenepoel | Zendy; Patrick C. D’Haese | Zendy

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Sclerostin: another bone-related protein related to all-cause mortality in haemodialysis?

Author(s) -

Liesbeth Viaene,

Geert J. Behets,

Kathleen Claes,

Björn Meijers,

Frank Blocki,

Vincent Brandenburg,

P. Evenepoel,

Patrick C. D’Haese

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft039

Subject(s) - sclerostin , medicine , hemodialysis , intensive care medicine , signal transduction , wnt signaling pathway , biochemistry , chemistry

Derangements in bone metabolism and vascular calcification (VC) substantially contribute to the accelerated cardiovascular morbidity and mortality in chronic kidney disease (CKD). The Wnt signalling pathway is increasingly recognized to play an important role in bone homeostasis and VC. Circulating levels of the Wnt inhibitor sclerostin are elevated in CKD patients. The present study investigated whether the circulating levels of sclerostin are associated with all-cause mortality in haemodialysis (HD) patients.

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