Open AccessAngiotensin-converting enzyme 2 activity in patients with chronic kidney disease
Author(s) -
Matthew A Roberts,
Elena Velkoska,
Francesco L. Ierino,
Louise M. Burrell
Publication year - 2013
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gft038
Subject(s) - medicine , kidney disease , angiotensin converting enzyme , renin–angiotensin system , kidney , enzyme , peptidyl dipeptidase a , endocrinology , biochemistry , blood pressure , chemistry
Angiotensin-converting enzyme 2 (ACE2) is a novel regulator of the renin-angiotensin system that counteracts the adverse effects of angiotensin II. In heart failure patients, elevated plasma ACE2 activity predicted adverse events and greater myocardial dysfunction. We aimed to describe plasma ACE2 activity and its clinical associations in patients with kidney disease.