Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (MDM)-2 | Zendy

Jan Hagemann | Zendy; Dana Thomasová | Zendy; Shrikant R. Mulay | Zendy; HansJoachim Anders | Zendy

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Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (MDM)-2

Author(s) -

Jan Hagemann,

Dana Thomasová,

Shrikant R. Mulay,

HansJoachim Anders

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft037

Subject(s) - sulforaphane , regeneration (biology) , microbiology and biotechnology , ex vivo , cell , biology , population , progenitor cell , chemistry , cancer research , immunology , stem cell , in vivo , medicine , biochemistry , environmental health

Tubular repair upon injury involves regeneration from either surviving tubular epithelial cells or from their surviving local progenitor cells; hence, compound screening with cell lines may be inadequate. Here, we demonstrate that the renal cell isolation procedure and subsequent outgrowth of tubular cells can mimic the renal injury phase and tubular cell regeneration from whichever surviving renal cells.

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