Kidney-protective effects of azelnidipine versus a diuretic in combination with olmesartan in hypertensive patients with diabetes and albuminuria: a randomized study | Zendy

M. Kojima | Zendy; S. Okubo | Zendy; Ryuichi Mizubayashi | Zendy; Naoki Isaka | Zendy; H. Machida | Zendy; Shinya Okamoto | Zendy; Hiroko HIROTA | Zendy; Masahiro Takeuchi | Zendy; Tsuyoshi Kato | Zendy; Kaname Nakatani | Zendy; Osamu Mizuno | Zendy; Koichi Miyagawa | Zendy; Keitaro Makino | Zendy; Takanori Okura | Zendy; Yasuaki Dohi | Zendy; Masaaki Ito | Zendy; Go Kimura | Zendy

Open Access

Kidney-protective effects of azelnidipine versus a diuretic in combination with olmesartan in hypertensive patients with diabetes and albuminuria: a randomized study

Author(s) -

M. Kojima,

S. Okubo,

Ryuichi Mizubayashi,

Naoki Isaka,

H. Machida,

Shinya Okamoto,

Hiroko HIROTA,

Masahiro Takeuchi,

Tsuyoshi Kato,

Kaname Nakatani,

Osamu Mizuno,

Koichi Miyagawa,

Keitaro Makino,

Takanori Okura,

Yasuaki Dohi,

Masaaki Ito,

Go Kimura

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft034

Subject(s) - medicine , amlodipine , albuminuria , urology , olmesartan , diuretic , creatinine , blood pressure , thiazide , endocrinology , hydrochlorothiazide , renal function

A thiazide diuretic used in combination with benazepril is superior to amlodipine plus benazepril in reducing albuminuria in hypertensive patients with diabetes. However, calcium channel blockers have diverse characteristics. Thus, we investigated whether combining an angiotensin receptor blocker with either azelnidipine or a thiazide diuretic produced similar reductions in albuminuria in hypertensive diabetic patients for the same levels of blood pressure achieved.

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