A new recombinant MnSOD prevents the Cyclosporine A-induced renal impairment | Zendy

Sara Damiano | Zendy; Francesco Trepiccione | Zendy; Roberto Ciarcia | Zendy; Roberto Scanni | Zendy; Manuela Spagnuolo | Zendy; Leonida Manco | Zendy; Antonella Borrelli | Zendy; Clemente Capasso | Zendy; Roberto E. Mancini | Zendy; Antonella Schiattarella | Zendy; Anna Iervolino | Zendy; Enza Zacchia | Zendy; Andrea Bata-Csere | Zendy; Salvatore Florio | Zendy; Pietro Anastasio | Zendy; Rosa Maria Pollastro | Zendy; Aldo Mancini | Zendy; Giovambattista Capasso | Zendy

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A new recombinant MnSOD prevents the Cyclosporine A-induced renal impairment

Author(s) -

Sara Damiano,

Francesco Trepiccione,

Roberto Ciarcia,

Roberto Scanni,

Manuela Spagnuolo,

Leonida Manco,

Antonella Borrelli,

Clemente Capasso,

Roberto E. Mancini,

Antonella Schiattarella,

Anna Iervolino,

Enza Zacchia,

Andrea Bata-Csere,

Salvatore Florio,

Pietro Anastasio,

Rosa Maria Pollastro,

Aldo Mancini,

Giovambattista Capasso

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft020

Subject(s) - medicine , renal function , nephrotoxicity , kidney , pharmacology , reactive oxygen species , abdominal aorta , endocrinology , kidney disease , aorta , biochemistry , chemistry

Cyclosporine A (CsA) is one of the most frequently used anticalcineurinic drugs for preventing graft rejection and autoimmune disease. Its use is hampered by nephrotoxic effects, namely an impairment of the glomerular filtration rate (GFR) and hypertension. Evidence suggests that reactive oxygen species (ROS) play a causal role in the nephrotoxicity. The present study aims to investigate in vivo the effects of a new recombinant mitochondrial manganese-containing superoxide dismutase (rMnSOD), a strong antioxidant, on the CsA-induced nephotoxicity.

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