Urinary sodium excretion is the main determinant of mineralocorticoid excretion rates in patients with chronic kidney disease | Zendy

Emily P. McQuarrie | Zendy; Ellen Marie Freel | Zendy; Patrick B. Mark | Zendy; Robert Fraser | Zendy; John Connell | Zendy; Alan G. Jardine | Zendy

Open Access

Urinary sodium excretion is the main determinant of mineralocorticoid excretion rates in patients with chronic kidney disease

Author(s) -

Emily P. McQuarrie,

Ellen Marie Freel,

Patrick B. Mark,

Robert Fraser,

John Connell,

Alan G. Jardine

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gft007

Subject(s) - medicine , kidney disease , excretion , endocrinology , renal function , urinary system , fractional excretion of sodium , context (archaeology) , mineralocorticoid , aldosterone , urology , biology , paleontology

Blockade of the mineralocorticoid receptor (MR) in patients with chronic kidney disease (CKD) improves surrogate cardiovascular outcomes, such as left ventricular mass. Animal models of renal disease support a pathological role of mineralocorticoids, in the context of a high sodium intake. We aimed to assess the regulation of mineralocorticoid biosynthesis in patients with CKD.

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