Humoral signalling compounds in remote ischaemic preconditioning of the kidney, a role for the opioid receptor | Zendy

Kimberley E. Wever | Zendy; Rosalinde Masereeuw | Zendy; Frank A. D. T. G. Wagener | Zendy; Viviènne Verweij | Zendy; Janny G.P. Peters | Zendy; Jeanne Pertijs | Zendy; J. Adam van der Vliet | Zendy; Michiel C. Warlé | Zendy; Gerard A. Rongen | Zendy

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Humoral signalling compounds in remote ischaemic preconditioning of the kidney, a role for the opioid receptor

Author(s) -

Kimberley E. Wever,

Rosalinde Masereeuw,

Frank A. D. T. G. Wagener,

Viviènne Verweij,

Janny G.P. Peters,

Jeanne Pertijs,

J. Adam van der Vliet,

Michiel C. Warlé,

Gerard A. Rongen

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs601

Subject(s) - medicine , ischemia , kidney , creatinine , hindlimb , pharmacology , renal function , ischemic preconditioning , acute kidney injury , renal ischemia , nitric oxide synthase , opioid receptor , antagonist , anesthesia , nitric oxide , reperfusion injury , receptor

Renal ischaemia-reperfusion injury (IRI) is a common clinical problem associated with significant mortality and morbidity. One strategy to reduce this damage is remote ischaemic preconditioning (RIPC), in which brief ischaemia of a limb protects the kidney against a prolonged ischaemic insult. The mechanism of renal RIPC has not yet been elucidated. Here, we address the gap in our understanding of renal RIPC signalling, using a rat model of renal IRI and RIPC by brief hind limb ischaemia.

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