Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate | Zendy

Takeo Nakanishi | Zendy; Kouhei Ohya | Zendy; Shoichi Shimada | Zendy; Naohiko Anzai | Zendy; Ikumi Tamai | Zendy

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Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate

Author(s) -

Takeo Nakanishi,

Kouhei Ohya,

Shoichi Shimada,

Naohiko Anzai,

Ikumi Tamai

Publication year - 2013

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfs574

Subject(s) - reabsorption , medicine , urinary system , renal physiology , cotransporter , kidney , endocrinology , chemistry , organic chemistry , sodium

Serum urate (SUA) level is affected by alteration in urinary reabsorption caused by clinically important drugs; however, there are no experimental models suitable to assess their effect on renal reabsorption. We, therefore, aimed to establish an experimental system co-expressing the urate transporters URAT1 (SLC22A12) and URATv1 (SLC2A9) (designated UUv cells) at the apical and basolateral membranes, respectively.

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